Lipid Signaling in Ocular Neovascularization

Ocular Neovascularization Caused by Herpes

Nuclear Factor Kappa-B Signaling Is Integral to Ocular Neovascularization in Ischemia-Independent Microenvironment

Retinal ischemia promotes the upregulation of VEGF expression and accounts for most pathological features of retinal neovascularization (NV). Paradoxically, VEGF remains the pivotal stimulator of ocular NV, despite the absence of ischemia. Therefore, the central question arises as to how the various molecular mechanisms interplay in ischemia-independent NV. It's been suggested that NFκB plays a...

Photodynamic therapy for neovascularization in lipid keratopathy.

Lipid keratopathy is a disease in which fat accumulates and feeding vessels penetrate the cornea. When fat accumulates at the center, visual acuity decreases. To date, no useful treatments have been confirmed, but favorable results appear to be obtained using photodynamic therapy. In photodynamic therapy for cancer, cells are selectively killed by intravenous injection of a light-sensitive subs...

Endocan Blockade Suppresses Experimental Ocular Neovascularization in Mice.

Purpose Ocular neovascularization (NV) is a pathologic process characterized by the proliferation and infiltration of various types of cells such as RPE, glial, and endothelial cells, which interact with proangiogenic factors and inflammatory cytokines. Endocan is known to be enriched in retinal endothelial tip cells under hypoxia, but the effect of endocan on ocular NV progression is largely u...

Ocular risk factors for choroidal neovascularization in pathologic myopia.

UNLABELLED PURPOSE. To identify the risk factors for development of myopic choroidal neovascularization (mCNV), a major cause of visual impairment. METHODS. Enrolled in the study were 23 consecutive patients with bilateral high myopia (axial length, > or =26.5 mm or refractive error, < or =8 D) and unilateral newly developed mCNV who presented to the Myopia Clinic, Osaka University Hospital. Sp...